Glutathione S-transferase, incense burning and asthma in children.

Genetic Polymorphisms of Glutathione S-Transferase mu1 (GSTM1) and Theta1(GSTT1) and Bronchial Asthma Susceptibility in Ukrainian Population

Home exposure to Arabian incense (bakhour) and asthma symptoms in children: a community survey in two regions in Oman

BACKGROUND Incense burning has been reported to adversely affect respiratory health. The aim of this study was to explore whether exposure to bakhour contributes to the prevalence of asthma and/or triggers its symptoms in Omani children by comparing two Omani regions with different prevalence of asthma. METHODS A randomly selected sample of 10 years old schoolchildren were surveyed using an A...

Gst M1 and T1 Gene Variants Deficiency with Passive Maternal Smoking during Pregnancy May Increase Asthma Risk in Indian Children

It has been evident that Glutathione S-transferase (GST) gene deficiency may contribute to the development of asthma. Therefore, we aimed to assess the association of GSTT1 and GSTM1 deficiency with passive maternal smoking (MS) during pregnancy with asthma in north Indian children. It was a hospital based case-control study, 175 bronchial asthma cases and 175 controls, aged 1 year -15 years we...

Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma.

BACKGROUND Microsomal epoxide hydrolase (EPHX1) metabolises xenobiotics including polyaromatic hydrocarbons (PAHs). Functional variants at this locus have been associated with respiratory diseases. The effects of EPHX1 variants may depend upon exposures from tobacco smoke and traffic emissions that contain PAHs as well as variants in other enzymes in the PAH metabolic pathway such as glutathion...

Glutathione S transferase theta1 and mu1 gene polymorphisms and phenotypic expression of asthma in Egyptian children: a case–control study

BACKGROUND Asthma is the result of a complex interaction between environmental factors and genetic variants that confer susceptibility. The glutathione S-transferases (GSTT1 and GSTM1) are phase II enzymes thought to protect the airways from oxidative stress. Few and contradictory data are available on the association between asthma development and GSTT1 and GSTM1 polymorphisms in different eth...